Send Email

Info@hope-chem.com

Working Hours

Mon-Fri 08:00AM - 06:00PM

Need Any Help?

+86-21-58090396

Product Detail

  • Entrectinib
  • Entrectinib
  • Entrectinib
  • Entrectinib

Entrectinib

  • CAS No.1108743-60-7:
  • Molecular Formula:C31H34F2N6O2:
  • Molecular Weight:560.6:
  • Reference Standard:In-house:
  • Documentation:TP:
  • Inquiry

Product Description

Entrectinib is an orally bioavailable inhibitor of the tyrosine kinases tropomyosin receptor kinases (Trk) A, B and C, C-ros oncogene 1 (ROS1) and anaplastic lymphoma kinase (ALK), with potential antineoplastic activity. Upon administration, entrectinib binds to and inhibits TrkA, TrkB, TrkC, ROS1 and ALK. Inhibition of these kinases may result in a disruption of TrkA-, TrkB-, TrkC-, ROS1-, and ALK-mediated signaling. This leads to an induction of apoptosis and an inhibition of tumor cell proliferation in tumor cells that express these kinases. TrkA, TrkB, TrkC, ROS1 and ALK are overexpressed in a variety of cancer cell types.

Hits: 【Print】