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  • Cabozantinib S-malate
  • Cabozantinib S-malate
  • Cabozantinib S-malate
  • Cabozantinib S-malate

Cabozantinib S-malate

  • CAS No.1140909-48-3:
  • Molecular Formula:C32H30FN3O10:
  • Molecular Weight:635.6:
  • Reference Standard:In-house:
  • Documentation:China DMF:
  • Inquiry

Product Description

Cabozantinib S-malate is the s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several RTKs, which are often overexpressed in a variety of cancer cell types, including hepatocyte growth factor receptor (MET), RET (rearranged during transfection), vascular endothelial growth factor receptor types 1 (VEGFR-1), 2 (VEGFR-2), and 3 (VEGFR-3), mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (TRKB) and AXL. This may result in an inhibition of both tumor growth and angiogenesis, and eventually lead to tumor regression.


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