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Product Detail

  • Venetoclax
  • Venetoclax
  • Venetoclax
  • Venetoclax


  • CAS No.1257044-40-8:
  • Molecular Formula:C45H50ClN7O7S:
  • Molecular Weight:868.4:
  • Reference Standard:In-house:
  • Documentation:TP:
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Product Description

Venetoclax is an orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. Venetoclax mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells. Bcl-2 protein is overexpressed in some cancers and plays an important role in the regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival. Compared to the Bcl-2 inhibitor navitoclax, this agent does not inhibit bcl-XL and does not cause bcl-XL-mediated thrombocytopenia.

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