Send Email

Info@hope-chem.com

Working Hours

Mon-Fri 08:00AM - 06:00PM

Need Any Help?

+86-21-58090396

Product Detail

  • Gilteritinib
  • Gilteritinib
  • Gilteritinib
  • Gilteritinib

Gilteritinib

  • CAS No.1254053-43-4:
  • Molecular Formula:C29H44N8O3:
  • Molecular Weight:552.7:
  • Reference Standard:In-house:
  • Documentation:TP:
  • Inqury

Product Description

Gilteritinib is an orally bioavailable inhibitor of the receptor tyrosine kinases (RTKs) FMS-related tyrosine kinase 3 (FLT3, STK1, or FLK2), AXL (UFO or JTK11) and anaplastic lymphoma kinase (ALK or CD246), with potential antineoplastic activity. Gilteritinib binds to and inhibits both the wild-type and mutated forms of FLT3, AXL and ALK. This may result in an inhibition of FLT3, AXL, and ALK-mediated signal transduction pathways and reduces tumor cell proliferation in cancer cell types that overexpress these RTKs. FLT3, AXL and ALK, overexpressed or mutated in a variety of cancer cell types, play a key role in tumor cell growth and survival.

Hits: 【Print】