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Product Detail

  • Gilteritinib
  • Gilteritinib
  • Gilteritinib
  • Gilteritinib


  • CAS No.1254053-43-4:
  • Molecular Formula:C29H44N8O3:
  • Molecular Weight:552.7:
  • Reference Standard:In-house:
  • Documentation:TP:
  • Inqury

Product Description

Gilteritinib is an orally bioavailable inhibitor of the receptor tyrosine kinases (RTKs) FMS-related tyrosine kinase 3 (FLT3, STK1, or FLK2), AXL (UFO or JTK11) and anaplastic lymphoma kinase (ALK or CD246), with potential antineoplastic activity. Gilteritinib binds to and inhibits both the wild-type and mutated forms of FLT3, AXL and ALK. This may result in an inhibition of FLT3, AXL, and ALK-mediated signal transduction pathways and reduces tumor cell proliferation in cancer cell types that overexpress these RTKs. FLT3, AXL and ALK, overexpressed or mutated in a variety of cancer cell types, play a key role in tumor cell growth and survival.

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